פעילות רפואית מוכחת מחקרית:

נוגד זיהום (וירוסים, פרזיטים, תולעים),

נוגד דלקת,

נוגד חמצון,

ממריץ חיסוני,

משקם/מגן כבד,

ממריץ ייצור מרה,

מפחית רמות סוכר,

נוגד קרישה,

נוגד סרטן.

מחקרים רבים שבוצעו מראים כי שימוש באנדרוגרפיס יכול לסייע לטיפול ושיפור של:

חולשה חיסונית, סרטן, דלקת כבד, כבד שומני, מחלות ויראליות (מניעה וטיפול), זיהומים במערכת העיכול, דלקת בדרכי המרה, דלקת בכיס המרה, אבני מרה, קנדידה, דלקות בדרכי השתן, פרונקלים וזיהומים תת-עוריים, שפעת והצטננות, סינוסיטיס, דלקת ריאות, סוכרת.

מקורות מחקריים

• מחקר שבדק את היתרונות של אנדרוגרפיס בטיפול בפריקת הגרון והאמידה בגורמים אלרגיים של מחלות הגרון והטונזילות. נמצא כי אנדרוגרפיס יכולה להקל על תסמיני הגרון הכרוניים ולהפחית את הדלקות הטונזילות.
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  מחקר זה בדק את ההשפעה של אנדרוגרפיס על פעילות החמצון של הכבד. נמצא כי תמצית אנדרוגרפיס עשויה לשפר את פעילות החמצון הנוגדת בכבד.
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• Ooi JP, Kuroyanagi M, Sulaiman SF, Muhammad TS, Tan ML. Andrographolide and 14-deoxy-11,12-didehydroandrographolide inhibit cytochrome P450s in HepG2 hepatoma cells. Life Sci. 2011 Feb 28;88(9-10):447-54. https://www.ncbi.nlm.nih.gov/pubmed/21219911
• Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CE. In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19). J Ethnopharmacol. 2011; 133:881–887. https://www.ncbi.nlm.nih.gov/pubmed/21093571
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• Uchaipichat V. In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humans. Drug Metab Pharmacokinet. 2018 Feb;33(1):67–76. https://www.ncbi.nlm.nih.gov/pubmed/29241692
• Chong YM, Kaur G, Tan ML. Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor. J Asian Nat Prod Res. 2019 Aug;21(8):754–71. https://www.ncbi.nlm.nih.gov/pubmed/30606060
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• Reyes, B., N. Bautista, N. Tanquilut, R. et al., 2006. Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats. Journal of Ethnopharmacology 105: 196–200. https://www.ncbi.nlm.nih.gov/pubmed/16298503
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